pentobarbital will reduce the extent or outcome of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay clear of use in patients who are chronically employing a powerful CYP3A4 inducerPentobarbital belongs to a class of remedies k